Synthesis of szentiamide, a depsipeptide from entomopathogenic Xenorhabdus 
szentirmaii with activity against Plasmodium falciparum

Nollmann, Friederike I.; Dowling, Andrea; Kaiser, Marcel; Deckmann, Klaus; Groesch, Sabine; Ffrench-Constant, Richard; Bode, Helge B.

doi:10.3762/bjoc.8.60

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Synthesis of szentiamide, a depsipeptide from entomopathogenic Xenorhabdus szentirmaii with activity against Plasmodium falciparum

MPS-Authors

There are no MPG-Authors in the publication available

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Nollmann, F. I., Dowling, A., Kaiser, M., Deckmann, K., Groesch, S., Ffrench-Constant, R., et al. (2012). Synthesis of szentiamide, a depsipeptide from entomopathogenic Xenorhabdus szentirmaii with activity against Plasmodium falciparum. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 8, 528-533. doi:10.3762/bjoc.8.60.

Cite as: https://hdl.handle.net/21.11116/0000-000A-0538-2

Abstract

The synthesis of the recently characterized depsipeptide szentiamide (1), which is produced by the entomopathogenic bacterium Xenorhabdus szentirmaii, is described. Whereas no biological activity was previously identified for 1, the material derived from the efficient synthesis enabled additional bioactivity tests leading to the identification of a notable activity against insect cells and Plasmodium falciparum, the causative agent of malaria.