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Clustered recurrent connectivity promotes the development of E/I co-tuning via synaptic plasticity

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Giannakakis, E., Vinogradov, O., & Levina, A. (2022). Clustered recurrent connectivity promotes the development of E/I co-tuning via synaptic plasticity. Poster presented at Computational and Systems Neuroscience Meeting (COSYNE 2022), Lisboa, Portugal.

Cite as: https://hdl.handle.net/21.11116/0000-000A-0344-6
Experimental studies have shown that cortical neurons often exhibit a co-tuning of their excitatory and inhibitory
receptive fields (i.e. correlation of incoming E/I currents for different input signals). Such co-tuning is hypothesised
to be important for efficient computations. Theoretical studies have examined how different plasticity mechanisms
can create such co-tuning in feedforward settings, where distinct, uncorrelated inputs to a post-synaptic neuron
allow the formation of matching excitatory and inhibitory receptive fields. Still, the cortex is characterized by high
levels of recurrence which raises the question of the mechanism by which input-driven E/I co-tuning arises. We
demonstrate that a possible mechanism of E/I co-tuning in recurrent settings is highly specific recurrent connectivity
which produces the necessary statistics for detailed balance to emerge. We first verify that in feedforward
networks a combination of triplet STDP on the excitatory synapses and symmetric homeostatic STDP on the
inhibitory synapses utilizes inhomogeneities in the pre-synaptic firing rates to create tightly matching excitatory
and inhibitory receptive fields. The addition of unstructured recurrent connectivity in the pre-synaptic layer can
significantly hamper the ability of STDP to produce co-tuning. We use simulation based inference to uncover possible
constraints on the topology of the recurrent connectivity that will allow matching receptive fields to emerge.
We find that different levels of clustering within neuron groups can effectively control the statistics of the input
the post-synaptic neuron receives and consequently the ability of the STDP to produce co-tuning. Specifically,
clustered excitation and global inhibition is particularly beneficial to developing E/I co-tuning. Our results suggest
that structured recurrent connectivity can boost information propagation and promote the development of input
selectivity in higher brain areas.