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Journal Article

Biosynthesis of volatiles by the myxobacterium Myxococcus xanthus

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Dickschat, J., Wenzel, S., Bode, H. B., Muller, R., & Schulz, S. (2004). Biosynthesis of volatiles by the myxobacterium Myxococcus xanthus. CHEMBIOCHEM, 5(6), 778-787. doi:10.1002/cbic.200300813.

Cite as: https://hdl.handle.net/21.11116/0000-000A-094A-A
The volatiles emitted from cell cultures of myxobacterium Myxococcus xanthus were collected by use of a closed-loop stripping apparatus (CLSA) and analyzed by GC-MS. Two new natural products, (S)-9-methyldecan-3-ol ((S)-1) and 9-methyldecan-3-one (2), were identified and synthesized, together with other aliphatic ketones and alcohols, and terpenes, Biosynthesis, of the two main components (S)-1 2 was examined in feeding experiments carried out with the wild-type strain DK1622 and two mutant strains JD300 and KD11017, which are impaired in the degradation pathway from leucine to isovaleryl-SCoA. Isovaleryl-SCoA is used as a starter, followed by chain elongation with two malonate units. Subsequent use of methyl malonate and decarboxylation leads to (S)-1 and 2. Furthermore, 3,3-dimethylacrylic acid (DMAA) can be used by the mutant strain to form isovaleryl- SCoA, which corroborates, recent data on the detection of a novel variety of the mevalonate pathway giving rise to isovaleryl-SCoA from HMGCoA.