Secondary metabolites by chemical screening, 42 - Cladospirones B to I from 
Sphaeropsidales sp F-24 ' 707 by variation of culture conditions

Bode, H. B.; Walker, M; Zeeck, A

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Secondary metabolites by chemical screening, 42 - Cladospirones B to I from Sphaeropsidales sp F-24 ' 707 by variation of culture conditions

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Bode, H. B., Walker, M., & Zeeck, A. (2000). Secondary metabolites by chemical screening, 42 - Cladospirones B to I from Sphaeropsidales sp F-24 ' 707 by variation of culture conditions. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2000(18), 3185-3193.

Cite as: https://hdl.handle.net/21.11116/0000-000A-0929-F

Abstract

Variation of the culture conditions - static surface cultures in particular - of the fungus Sphaeropsidales sp. (strain F-24'707), which produces cladospirone bisepoxide (1), led to the isolation of eight new spirobisnaphthalenes - the cladospirones B to I (8-15) -together with seven known representatives of this class of secondary metabolites. Cladospirones C (9) and D (11) show antibiotic activity against bacteria and algae. The structures of cladospirone B (8) and E (12) were confirmed by X-ray structure analysis. Cladospirones C (9) and G to I (10, 14-15) represent new members of the spirobis-naphthalene family, thanks to their hydroxylation patterns. Moreover, they underline the extraordinary status of this interesting class of compounds as the most diverse secondary metabolites, allowing for their small number of carbon atoms, described to date. Almost all possible permutations of stereochemistry and oxygen substitution pattern on the C-10 skeleton are produced by different fungi.