Reactive oxygen species (ROS) constitute an additional player in regulating 
epithelial development.

Hebbar, Sarita; Knust, Elisabeth

doi:10.1002/bies.202100096

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Reactive oxygen species (ROS) constitute an additional player in regulating epithelial development.

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Hebbar, Sarita
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Knust, Elisabeth
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Hebbar, S., & Knust, E. (2021). Reactive oxygen species (ROS) constitute an additional player in regulating epithelial development. BioEssays: news and reviews in molecular, cellular and developmental biology, 43(8): 2100096. doi:10.1002/bies.202100096.

Cite as: https://hdl.handle.net/21.11116/0000-000A-0BB5-E

Abstract

Reactive oxygen species (ROS) are highly reactive molecules produced in cells. So far, they have mostly been connected to diseases and pathological conditions. More recent results revealed a somewhat unexpected role of ROS in control of developmental processes. In this review, we elaborate on ROS in development, focussing on their connection to epithelial tissue morphogenesis. After briefly summarising unique characteristics of epithelial cells, we present some characteristic features of ROS species, their production and targets, with a focus on proteins important for epithelial development and function. Finally, we provide examples of regulation of epithelial morphogenesis by ROS, and also of developmental genes that regulate the overall redox status. We conclude by discussing future avenues of research that will further elucidate ROS regulation in epithelial development.