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Journal Article

The RNA binding protein human antigen R is a gatekeeper of liver homeostasis.

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Grzybek,  Michal
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Haase,  Robert
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Domingues,  Antonio
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

/persons/resource/persons219236

Henry,  Ian
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Subramanian, P., Gargani, S., Palladini, A., Chatzimike, M., Grzybek, M., Peitzsch, M., et al. (2021). The RNA binding protein human antigen R is a gatekeeper of liver homeostasis. Hepatology (Baltimore, Md.), doi: 10.1002/hep.32153. doi:10.1002/hep.32153.


Cite as: https://hdl.handle.net/21.11116/0000-000A-0BC5-C
Abstract
Non-alcoholic fatty liver disease (NAFLD) is initiated by steatosis and can progress via fibrosis and cirrhosis to hepatocellular carcinoma (HCC). The RNA binding protein HuR controls RNAs at the posttranscriptional level; hepatocyte HuR has been implicated in the regulation of diet-induced hepatic steatosis. The present study aimed to understand the role of hepatocyte-HuR in NAFLD development and progression to fibrosis and HCC.