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Transcriptome signature of miRNA-26b KO mouse model suggests novel targets.

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Naumann,  Ronald
Max Planck Institute for Molecular Cell Biology and Genetics, Max Planck Society;

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Citation

Vorst, E. P. C. v. d., Pepe, M. A. A., Peters, L. J. F., Haberbosch, M., Jansen, Y., Naumann, R., et al. (2021). Transcriptome signature of miRNA-26b KO mouse model suggests novel targets. BMC genomic data, 22(1): 23. doi:10.1186/s12863-021-00976-1.


Cite as: https://hdl.handle.net/21.11116/0000-000A-0BD1-E
Abstract
MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. One of the miRNAs that has been shown to play a role in various pathologies like cancer, neurological disorders and cardiovascular diseases is miRNA-26b. However, these studies only demonstrated rather ambiguous associations without revealing a causal relationship. Therefore, the aim of this study is to establish and validate a mouse model which enables the elucidation of the exact role of miRNA-26b in various pathologies.