Avoid shocking your hematopoietic stem cells to keep them young and growing

Lalioti, Maria-Eleni; Rettkowski, Jasmin; Cabezas-Wallscheid, Nina

doi:10.1016/j.stem.2021.10.007

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Journal Article

Avoid shocking your hematopoietic stem cells to keep them young and growing

MPS-Authors

Lalioti, Maria-Eleni
Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

Rettkowski, Jasmin
Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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Cabezas-Wallscheid, Nina
Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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https://www.sciencedirect.com/science/article/abs/pii/S1934590921004197
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Citation

Lalioti, M.-E., Rettkowski, J., & Cabezas-Wallscheid, N. (2021). Avoid shocking your hematopoietic stem cells to keep them young and growing. Cell Stem Cell, 28, 1887-1889. doi:10.1016/j.stem.2021.10.007.

Cite as: https://hdl.handle.net/21.11116/0000-000A-1120-E

Abstract

Expanding hematopoietic stem cells (HSCs) ex vivo has historically been a very challenging process. In this
issue of Cell Stem Cell, Kruta et al. (2021) identify heat shock factor 1 (Hsf1) as a new target to maintain HSC
fitness and protein homeostasis, not only in culture conditions but also upon aging.