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Journal Article

Alternative Polyadenylation in Stem Cell Self-Renewal and Differentiation

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Cabezas-Wallscheid,  Nina
Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society;

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https://www.sciencedirect.com/science/article/abs/pii/S1471491421001015
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Citation

Sommerkamp, P., Cabezas-Wallscheid, N., & Trumpp, A. (2021). Alternative Polyadenylation in Stem Cell Self-Renewal and Differentiation. Trends in Molecular Medicine, 27, 660-672. doi:10.1016/j.molmed.2021.04.006.


Cite as: https://hdl.handle.net/21.11116/0000-000A-1298-6
Abstract
Cellular function is shaped by transcriptional and post-transcriptional mechanisms, including alternative polyadenylation (APA). By directly controlling 3′- untranslated region (UTR) length and the selection of the last exon, APA regulates up to 70% of all cellular transcripts influencing RNA stability, output, and protein isoform expression. Cell-state-dependent 3′-UTR shortening has been identified as a hallmark of cellular proliferation. Hence, quiescent/dormant stem cells are characterized by long 3′-UTRs, whereas proliferative stem/progenitor cells exhibit 3′-UTR shortening. Here, the latest studies analyzing the role of APA in regulating stem cell state, self-renewal, differentiation, and metabolism are reviewed. The new role of APA in controlling stem cell fate opens novel potential therapeutic avenues in the field of regenerative medicine.