Bypassing the nuclear gate: A non-canonical entry pathway for the mitochondrial 
pyruvate dehydrogenase complex

Boyle, Emily; Wilfling, Florian

doi:10.1016/j.molcel.2022.02.014

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Bypassing the nuclear gate: A non-canonical entry pathway for the mitochondrial pyruvate dehydrogenase complex

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Boyle, Emily
Research Group Mechanisms of Cellular Quality Control, Max Planck Institute of Biophysics, Max Planck Society;

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Wilfling, Florian
Research Group Mechanisms of Cellular Quality Control, Max Planck Institute of Biophysics, Max Planck Society;

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引用

Boyle, E., & Wilfling, F. (2022). Bypassing the nuclear gate: A non-canonical entry pathway for the mitochondrial pyruvate dehydrogenase complex. Molecular Cell, 82(5), 886-888. doi:10.1016/j.molcel.2022.02.014.

引用: https://hdl.handle.net/21.11116/0000-000A-142A-1

要旨

Zervopoulos et al. (2022) propose a non-canonical nuclear import pathway for the functional mitochondrial pyruvate dehydrogenase complex (PDC), facilitated by dynamic MFN2-mediated tethering of mitochondria to the nuclear envelope upon exposure to proliferative stimuli.