A Perspective on Late-Stage Aromatic C–H Bond Functionalization

Zhang, Li; Ritter, Tobias

doi:10.1021/jacs.1c10783

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

A Perspective on Late-Stage Aromatic C–H Bond Functionalization

MPS-Authors

/persons/resource/persons262262

Zhang, Li
Research Department Ritter, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

/persons/resource/persons198096

Ritter, Tobias
Research Department Ritter, Max-Planck-Institut für Kohlenforschung, Max Planck Society;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Zhang, L., & Ritter, T. (2022). A Perspective on Late-Stage Aromatic C–H Bond Functionalization. Journal of the American Chemical Society, 144(6), 2399-2414. doi:10.1021/jacs.1c10783.

Cite as: https://hdl.handle.net/21.11116/0000-000A-2DD2-7

Abstract

Late-stage functionalization of C–H bonds (C–H LSF) can provide a straightforward approach to the efficient synthesis of functionalized complex molecules. However, C–H LSF is challenging because the C–H bond must be functionalized in the presence of various other functional groups. In this Perspective, we evaluate aromatic C–H LSF on the basis of four criteria─reactivity, chemoselectivity, site-selectivity, and substrate scope─and provide our own views on current challenges as well as promising strategies and areas of growth going forward.