Mechanistic studies of GID/CTLH E3 ubiquitin ligases

Chrustowicz, Jakub

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Mechanistic studies of GID/CTLH E3 ubiquitin ligases

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Chrustowicz, Jakub
Schulman, Brenda / Molecular Machines and Signaling, Max Planck Institute of Biochemistry, Max Planck Society;

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Chrustowicz, J. (2022). Mechanistic studies of GID/CTLH E3 ubiquitin ligases. PhD Thesis, TUM, Fakultät für Chemie, München.

Cite as: https://hdl.handle.net/21.11116/0000-000A-3B57-3

Abstract

The integrative structural, biochemical, and cell biology data revealed mechanistic
principles of substrate targeting by evolutionarily conserved GID/CTLH E3 ubiquitin
ligases. The pliable substrate receptors adapt their conformations to recognize various
N-terminal peptide/degron sequences, whereas the chelator-like supramolecular
assembly of a catalytically active E3 ligase core configures multi-pronged targeting of
oligomeric substrates. The revealed principles provide a conceptual framework for
understanding the emerging complexity of the GID E3 ligase family.