Cellular Traffic Jam and Disease Due to Mutations in SRP54

Weichenrieder, O

doi:10.1016/j.str.2020.12.010

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Cellular Traffic Jam and Disease Due to Mutations in SRP54

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Weichenrieder, O
Structural Biology of Selfish RNA Group, Department Protein Evolution, Max Planck Institute for Developmental Biology, Max Planck Society;
Department Protein Evolution, Max Planck Institute for Developmental Biology, Max Planck Society;

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Citation

Weichenrieder, O. (2021). Cellular Traffic Jam and Disease Due to Mutations in SRP54. Structure, 29(1), 3-5. doi:10.1016/j.str.2020.12.010.

Cite as: https://hdl.handle.net/21.11116/0000-000A-532C-8

Abstract

In this issue of Structure, Juaire et al. use X-ray crystallography, biophysical tools, and cell-based assays to investigate disease-associated variants of the SRP54 GTPase and to demonstrate that defects in SRP-mediated protein secretion can explain phenotypes of severe neutropenia with Shwachman-Diamond-syndrome-like symptoms.