Molecular Logic of Prokaryotic Surface Layer Structures

Bharat, TAM; von Kügelgen, A; Alva, V

doi:10.1016/j.tim.2020.09.009

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Molecular Logic of Prokaryotic Surface Layer Structures

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Alva, V
Department Protein Evolution, Max Planck Institute for Developmental Biology, Max Planck Society;
Protein Bioinformatics Group, Department Protein Evolution, Max Planck Institute for Developmental Biology, Max Planck Society;

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Bharat, T., von Kügelgen, A., & Alva, V. (2021). Molecular Logic of Prokaryotic Surface Layer Structures. Trends in Microbiology, 29(5), 405-415. doi:10.1016/j.tim.2020.09.009.

Cite as: https://hdl.handle.net/21.11116/0000-000A-543E-3

Abstract

Most prokaryotic cells are encased in a surface layer (S-layer) consisting of a paracrystalline array of repeating lattice-forming proteins. S-layer proteins populate a vast and diverse sequence space, performing disparate functions in prokaryotic cells, including cellular defense, cell-shape maintenance, and regulation of import and export of materials. This article highlights recent advances in the understanding of S-layer structure and assembly, made possible by rapidly evolving structural and cell biology methods. We underscore shared assembly principles revealed by recent work and discuss a common molecular framework that may be used to understand the structural organization of S-layer proteins across bacteria and archaea