Quantitative 3D Mapping of Cr and PCr Concentrations at 3T using Snapshot AREX 
CEST MRI

Perlman, O; Coll-Fon, J; Herz, K; Zaiss, M; Nguyen, C; Farrar, CT

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Quantitative 3D Mapping of Cr and PCr Concentrations at 3T using Snapshot AREX CEST MRI

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Herz, K
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Zaiss, M
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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https://submissions.mirasmart.com/ISMRM2022/Itinerary/ConferenceMatrixEventDetail.aspx?ses=D-68
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Citation

Perlman, O., Coll-Fon, J., Herz, K., Zaiss, M., Nguyen, C., & Farrar, C. (2022). Quantitative 3D Mapping of Cr and PCr Concentrations at 3T using Snapshot AREX CEST MRI. Poster presented at Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting (ISMRM 2022), London, UK.

Cite as: https://hdl.handle.net/21.11116/0000-000A-5C55-0

Abstract

The dynamics of creatine and phosphocreatine distributions provide an important means for assessing metabolic function. While CEST-weighted MRI allows for the imaging of metabolite alterations, it is affected by semisolid-MT, spillover, and T1 contributions, and is typically analyzed on a two-dimensional image, given the inherently long acquisition times. Here, we performed 3D quantitative mapping of Cr and PCr concentrations in the human calf muscle at 3T, using a rapid snapshot-CEST protocol followed by apparent exchange-dependent relaxation (AREX) analysis. Significant (p<0.001) changes in the concentrations of both creatine and phosphocreatine were measured during exercise, in agreement with the literature.