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Deuterium Metabolic Imaging of the Human Brain in vivo at 7T

MPS-Authors
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Ruhm,  L
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Avdievich,  NI
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Henning,  A
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Roig, E., De Feyter, H., Nixon, T., Ruhm, L., Avdievich, N., Henning, A., et al. (2022). Deuterium Metabolic Imaging of the Human Brain in vivo at 7T. In Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting (ISMRM 2022).


Cite as: http://hdl.handle.net/21.11116/0000-000A-5C8F-F
Abstract
Brain energy metabolism, for which glucose is the main fuel, is essential not only for normal brain function but also for its active role in the mechanisms that underly brain diseases. Deuterium Metabolic Imaging (DMI) is a promising MR modality for investigating whole brain energy metabolism in humans at ultra-high field. In this study, we explore the potential of DMI in the human brain in vivo at 7T. We present whole brain 3D DMI maps of well-resolved deuterated (2H) metabolite resonances of water, glucose and glutamate/glutamine (Glx) following oral administration of [6,6’-2H2]-labelled glucose.