Observation of 2H labeled compounds in the human brain with 1H versus 2H 
magnetic resonance spectroscopy at 9.4T

Ruhm, L; Ziegs, T; Wright, A; Avdievich, N; Henning, A

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Observation of 2H labeled compounds in the human brain with 1H versus 2H magnetic resonance spectroscopy at 9.4T

MPS-Authors

/persons/resource/persons215122

Ruhm, L
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons215132

Ziegs, T
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons215127

Wright, A
Institutional Guests, Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons133464

Avdievich, N
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons84402

Henning, A
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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https://submissions.mirasmart.com/ISMRM2022/Itinerary/ConferenceMatrixEventDetail.aspx?id=152
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Citation

Ruhm, L., Ziegs, T., Wright, A., Avdievich, N., & Henning, A. (2022). Observation of 2H labeled compounds in the human brain with 1H versus 2H magnetic resonance spectroscopy at 9.4T. In Joint Annual Meeting ISMRM-ESMRMB & ISMRT 31st Annual Meeting (ISMRM 2022).

Cite as: https://hdl.handle.net/21.11116/0000-000A-5C93-9

Abstract

The tracing of glucose metabolism is of interest in many pathologies of the human brain. In this abstract, we compare the information content of 2H MRSI detected deuterium metabolic imaging (DMI) to quantitative exchanged-labeled turnover 1H MRS (QELT), both measured at B0 = 9.4 Tesla. An uptake of 2H labeling was detectable for different metabolites for both methods. Consistent changes in 2H labeled Glx after the oral administration of [6,6’-2H2]-glucose were detected in the brain of healthy human subjects.