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Journal Article

Advanced rules of relays

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Lorenz,  Sonja       
University of Würzburg, External Organizations;
Research Group Ubiquitin Signaling Specificity, MPI for Biophysical Chemistry, Max Planck Society;

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Citation

Lorenz, S., & Rittinger, K. (2020). Advanced rules of relays. Nature Chemical Biology, 16(11), 1158-1159. doi:10.1038/s41589-020-0632-8.


Cite as: https://hdl.handle.net/21.11116/0000-000A-60FD-D
Abstract
Transfer of ubiquitin onto target proteins requires controlled interplay between E2 conjugating enzymes and E3 ligases. The structure of a trapped E2~Ub/RCR E3 transfer intermediate provides novel insight into the diversity of mechanisms used to fine tune this relay.