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The Cdk1/Cdk2 homolog CDKA;1 controls the recombination landscape in Arabidopsis

MPG-Autoren
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Bayer,  M
Department Cell Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Zitation

Wijnker, E., Harashima, H., Müller, K., Parra-Nuñez, P., de Snoo, C., van de Belt, J., et al. (2019). The Cdk1/Cdk2 homolog CDKA;1 controls the recombination landscape in Arabidopsis. Proceedings of the National Academy of Sciences of the United States of America, 116(25), 12534-12539. doi:10.1073/pnas.1820753116.


Zitierlink: https://hdl.handle.net/21.11116/0000-000A-68B3-7
Zusammenfassung
Little is known how patterns of cross-over (CO) numbers and distribution during meiosis are established. Here, we reveal that cyclin-dependent kinase A;1 (CDKA;1), the homolog of human Cdk1 and Cdk2, is a major regulator of meiotic recombination in Arabidopsis Arabidopsis plants with reduced CDKA;1 activity experienced a decrease of class I COs, especially lowering recombination rates in centromere-proximal regions. Interestingly, this reduction of type I CO did not affect CO assurance, a mechanism by which each chromosome receives at least one CO, resulting in all chromosomes exhibiting similar genetic lengths in weak loss-of-function cdka ;1 mutants. Conversely, an increase of CDKA;1 activity resulted in elevated recombination frequencies. Thus, modulation of CDKA;1 kinase activity affects the number and placement of COs along the chromosome axis in a dose-dependent manner.