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Book Chapter

Optogenetic Control of TGF-β Signaling

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Zi,  Zhike
Cell Signaling Dynamics (Zhike Zi), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Li,  Yuchao
Cell Signaling Dynamics (Zhike Zi), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Citation

Zi, Z., & Li, Y. (2022). Optogenetic Control of TGF-β Signaling. In Z. Zi, & Liu, Xuedong (Eds.), TGF-Beta Signaling (pp. 113-124). Totowa. New Jersey: Humana Press. doi:10.1007/978-1-0716-2277-3_9.


Cite as: https://hdl.handle.net/21.11116/0000-000A-7315-D
Abstract
Cells employ signaling pathways to make decisions in response to changes in their immediate environment. The Transforming Growth Factor β (TGF-β) signaling pathway plays pivotal roles in regulating many cellular processes, including cell proliferation, differentiation, and migrations. In order to manipulate and explore the dynamic behavior of TGF-β signaling at high spatiotemporal resolution, we developed an optogenetic system (the optoTGFBRs system), in which light is used to control TGF-β signaling precisely in time and space. Here, we describe about experimental details of how to build the optoTGFBRs system and utilize it to manipulate TGF-β signaling in a single cell or a cell population using microscope or LED array, respectively.