Comment on "Ancient origins of allosteric activation in a Ser-Thr kinase"

Park, Y.; Patton, J. E. J.; Hochberg, G. K. A.; Thornton, J. W.

doi:10.1126/science.abc8301

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Comment on "Ancient origins of allosteric activation in a Ser-Thr kinase"

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Hochberg, G. K. A.
Max Planck Research Group Evolutionary Biochemistry, Max Planck Institute for Terrestrial Microbiology, Max Planck Society;

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https://www.ncbi.nlm.nih.gov/pubmed/33214251
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Citation

Park, Y., Patton, J. E. J., Hochberg, G. K. A., & Thornton, J. W. (2020). Comment on "Ancient origins of allosteric activation in a Ser-Thr kinase". Science, 370(6519). doi:10.1126/science.abc8301.

Cite as: https://hdl.handle.net/21.11116/0000-000A-76A5-7

Abstract

Hadzipasic et al (Reports, 21 February 2020, p. 912) used ancestral sequence reconstruction to identify historical sequence substitutions that putatively caused Aurora kinases to evolve allosteric regulation. We show that their results arise from using an implausible phylogeny and sparse sequence sampling. Addressing either problem reverses their inferences: Allostery and the amino acids that confer it were not gained during the diversification of eukaryotes but were lost in a subgroup of Fungi.