PHF13: A new player involved in RNA polymerase II transcriptional regulation 
and co-transcriptional splicing

Fuchs, Alisa; Torroba, Marcos; Kinkley, Sarah

doi:10.1080/21541264.2016.1274813

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PHF13: A new player involved in RNA polymerase II transcriptional regulation and co-transcriptional splicing

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Fuchs, Alisa
Computational Epigenetics (Ho-Ryun Chung), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society;

Torroba, Marcos
Computational Epigenetics (Ho-Ryun Chung), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Kinkley, Sarah
Computational Epigenetics (Ho-Ryun Chung), Independent Junior Research Groups (OWL), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Citation

Fuchs, A., Torroba, M., & Kinkley, S. (2017). PHF13: A new player involved in RNA polymerase II transcriptional regulation and co-transcriptional splicing. Transcription, 8(2), 106-112. doi:10.1080/21541264.2016.1274813.

Cite as: https://hdl.handle.net/21.11116/0000-000A-7A64-D

Abstract

We recently identified PHF13 as an H3K4me2/3 chromatin reader and transcriptional co-regulator. We found that PHF13 interacts with RNAPIIS5P and PRC2 stabilizing their association with active and bivalent promoters. Furthermore, mass spectrometry analysis identified ∼50 spliceosomal proteins in PHF13s interactome. Here, we will discuss the potential role of PHF13 in RNAPII pausing and co-transcriptional splicing.