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Resting-state fMRI functional connectivity strength predicts local activity change in the dorsal cingulate cortex: A multi-target focused rTMS study

MPG-Autoren
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Knösche,  Thomas R.
Methods and Development Group Brain Networks, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Zitation

Feng, Z.-J., Deng, X.-P., Zhao, N., Jin, J., Yue, J., Hu, Y.-S., et al. (2021). Resting-state fMRI functional connectivity strength predicts local activity change in the dorsal cingulate cortex: A multi-target focused rTMS study. Cerebral Cortex. doi:10.1093/cercor/bhab380.


Zitierlink: https://hdl.handle.net/21.11116/0000-000A-7BD3-E
Zusammenfassung
Previous resting state functional magnetic resonance imaging (RS-fMRI) studies suggested that repetitive transcranial magnetic stimulation (rTMS) can modulate local activity in distant areas via functional connectivity (FC). A brain region has more than one connection with the superficial cortical areas. The current study proposed a multi-target focused rTMS protocol for indirectly stimulating a deep region, and to investigate 1) whether FC strength between stimulation targets (right middle frontal gyrus [rMFG] and right inferior parietal lobule [rIPL]) and effective region (dorsal anterior cingulate cortex [dACC]) can predict local activity changes of dACC and 2) whether multiple stimulation targets can focus on the dACC via FC. A total of 24 healthy participants received rTMS with two stimulation targets, both showing strong FC with the dACC. There were four rTMS conditions (>1 week apart, 10 Hz, 1800 pulses for each): rMFG-target, rIPL-target, Double-targets (900 pulses for each target), and Sham. The results failed to validate the multi-target focused rTMS hypothesis. But rMFG-target significantly decreased the local activity in the dACC. In addition, stronger dACC-rMFG FC was associated with a greater local activity change in the dACC. Future studies should use stronger FC to focus stimulation effects on the deep region.