Identification of Protein Scaffolds for Enzyme Design Using Scaffold Selection

Stiel, AC; Feldmeier, K; Höcker, B

doi:10.1007/978-1-4939-1486-9_9

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Identification of Protein Scaffolds for Enzyme Design Using Scaffold Selection

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Stiel, AC
Research Group Protein Design, Max Planck Institute for Developmental Biology, Max Planck Society;

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Feldmeier, K
IMPRS From Molecules to Organisms, Max Planck Institute for Developmental Biology, Max Planck Society;

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Höcker, B
Research Group Protein Design, Max Planck Institute for Developmental Biology, Max Planck Society;

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Stiel, A., Feldmeier, K., & Höcker, B. (2014). Identification of Protein Scaffolds for Enzyme Design Using Scaffold Selection. In Methods in Molecular Biology. US: Springer.

引用: https://hdl.handle.net/21.11116/0000-000A-7C54-D

要旨

The identification of suitable protein structures that can serve as scaffolds for the introduction of catalytic residues is crucial for the design of new enzymes. Here we describe how the automated and rapid scaffold search program ScaffoldSelection can be used to find the best starting points, namely protein structures that are most likely to tolerate the introduction and promote the proper formation of a specific catalytic motif.