Regulation of MIR165/166 by class II and class III homeodomain leucine zipper 
proteins establishes leaf polarity

Merelo, P; Ram, H; Caggiano, MP; Ohno, C; Ott, F; Straub, D; Cho, SK; Yang, SW; Wenkel, S; Heisler, MG

doi:10.1073/pnas.1516110113

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Regulation of MIR165/166 by class II and class III homeodomain leucine zipper proteins establishes leaf polarity

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Ott, F
Department Molecular Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Citation

Merelo, P., Ram, H., Caggiano, M., Ohno, C., Ott, F., Straub, D., et al. (2016). Regulation of MIR165/166 by class II and class III homeodomain leucine zipper proteins establishes leaf polarity. Proceedings of the National Academy of Sciences of the United States of America, 113(42), 11973-11978. doi:10.1073/pnas.1516110113.

Cite as: https://hdl.handle.net/21.11116/0000-000A-7F15-1

Abstract

A defining feature of plant leaves is their flattened shape. This shape depends on an antagonism between the genes that specify adaxial (top) and abaxial (bottom) tissue identity; however, the molecular nature of this antagonism remains poorly understood. Class III homeodomain leucine zipper (HD-ZIP) transcription factors are key mediators in the regulation of adaxial-abaxial patterning. Their expression is restricted adaxially during early development by the abaxially expressed microRNA (MIR)165/166, yet the mechanism that restricts MIR165/166 expression to abaxial leaf tissues remains unknown. Here, we show that class III and class II HD-ZIP proteins act together to repress MIR165/166 via a conserved cis-element in their promoters. Organ morphology and tissue patterning in plants, therefore, depend on a bidirectional repressive circuit involving a set of miRNAs and its targets.