English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

A unified 3D map of microscopic architecture and MRI of the human brain

MPS-Authors
/persons/resource/persons23475

Bazin,  Pierre-Louis
Integrative Model-Based Cognitive Neuroscience Research Unit (IMCN), University of Amsterdam, the Netherlands;
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons188645

Pine,  Kerrin
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons180061

Kirilina,  Evgeniya
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Neurocomputation and Neuroimaging Unit, Department of Education and Psychology, FU Berlin, Germany;

/persons/resource/persons19864

Möller,  Harald E.       
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons20053

Trampel,  Robert
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

/persons/resource/persons147461

Weiskopf,  Nikolaus
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Felix Bloch Institute for Solid State Physics, University of Leipzig, Germany;
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)

Alkemade_2022.pdf
(Publisher version), 5MB

Supplementary Material (public)
There is no public supplementary material available
Citation

Alkemade, A., Bazin, P.-L., Balesar, R., Pine, K., Kirilina, E., Möller, H. E., et al. (2022). A unified 3D map of microscopic architecture and MRI of the human brain. Science Advances, 8(17): eabj7892. doi:10.1126/sciadv.abj7892.


Cite as: https://hdl.handle.net/21.11116/0000-000A-8208-A
Abstract
We present the first three-dimensional (3D) concordance maps of cyto- and fiber architecture of the human brain, combining histology, immunohistochemistry, and 7-T quantitative magnetic resonance imaging (MRI), in two individual specimens. These 3D maps each integrate data from approximately 800 microscopy sections per brain, showing neuronal and glial cell bodies, nerve fibers, and interneuronal populations, as well as ultrahigh-field quantitative MRI, all coaligned at the 200-μm scale to the stacked blockface images obtained during sectioning. These unprecedented 3D multimodal datasets are shared without any restrictions and provide a unique resource for the joint study of cell and fiber architecture of the brain, detailed anatomical atlasing, or modeling of the microscopic underpinnings of MRI contrasts.