A unified 3D map of microscopic architecture and MRI of the human brain

Alkemade, Anneke; Bazin, Pierre-Louis; Balesar, Rawien; Pine, Kerrin; Kirilina, Evgeniya; Möller, Harald E.; Trampel, Robert; Kros, Johan M.; Keuken, Max C.; Bleys, Ronald L. A. W.; Swaab, Dick F.; Herrler, Andreas; Weiskopf, Nikolaus; Forstmann, Birte U.

doi:10.1126/sciadv.abj7892

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A unified 3D map of microscopic architecture and MRI of the human brain

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Bazin, Pierre-Louis
Integrative Model-Based Cognitive Neuroscience Research Unit (IMCN), University of Amsterdam, the Netherlands;
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Pine, Kerrin
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Kirilina, Evgeniya
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Neurocomputation and Neuroimaging Unit, Department of Education and Psychology, FU Berlin, Germany;

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Möller, Harald E.
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Trampel, Robert
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Weiskopf, Nikolaus
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Felix Bloch Institute for Solid State Physics, University of Leipzig, Germany;
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, United Kingdom;

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Citation

Alkemade, A., Bazin, P.-L., Balesar, R., Pine, K., Kirilina, E., Möller, H. E., et al. (2022). A unified 3D map of microscopic architecture and MRI of the human brain. Science Advances, 8(17): eabj7892. doi:10.1126/sciadv.abj7892.

Cite as: https://hdl.handle.net/21.11116/0000-000A-8208-A

Abstract

We present the first three-dimensional (3D) concordance maps of cyto- and fiber architecture of the human brain, combining histology, immunohistochemistry, and 7-T quantitative magnetic resonance imaging (MRI), in two individual specimens. These 3D maps each integrate data from approximately 800 microscopy sections per brain, showing neuronal and glial cell bodies, nerve fibers, and interneuronal populations, as well as ultrahigh-field quantitative MRI, all coaligned at the 200-μm scale to the stacked blockface images obtained during sectioning. These unprecedented 3D multimodal datasets are shared without any restrictions and provide a unique resource for the joint study of cell and fiber architecture of the brain, detailed anatomical atlasing, or modeling of the microscopic underpinnings of MRI contrasts.