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Journal Article

Genetic analysis of fin formation in the zebrafish, Danio rerio

MPS-Authors
/persons/resource/persons274409

van Eeden,  FJ
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons274425

Granato,  M
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons274034

Schach,  U
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons219033

Brand,  M
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons274429

Furutani-Seiki,  M
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons274411

Haffter,  P
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons191086

Hammerschmidt,  M
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons219231

Heisenberg,  CP
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons274433

Jiang,  Y-J
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons274435

Kane,  DA
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons274437

Kelsh,  RN
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons274439

Mullins,  MC
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons274416

Odenthal,  J
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons274441

Warga,  RM
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons271460

Nüsslein-Volhard,  C
Department Genetics, Max Planck Institute for Developmental Biology, Max Planck Society;

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Citation

van Eeden, F., Granato, M., Schach, U., Brand, M., Furutani-Seiki, M., Haffter, P., et al. (1996). Genetic analysis of fin formation in the zebrafish, Danio rerio. Development, 123(1), 255-262. doi:10.1242/dev.123.1.255.


Cite as: https://hdl.handle.net/21.11116/0000-000A-82EA-B
Abstract
In the zebrafish, Danio rerio, a caudal and pectoral fin fold develop during embryogenesis. At larval stages the caudal fin fold is replaced by four different fins, the unpaired anal, dorsal and tail fins. In addition the paired pelvic fins are formed. We have identified a total of 118 mutations affecting larval fin formation. Mutations in 11 genes lead to abnormal morphology or degeneration of both caudal and pectoral fin folds. Most mutants survive to adulthood and form a surprisingly normal complement of adult fins. Mutations in nine genes result in an increased or reduced size of the pectoral fins. Interestingly, in mutants of one of these genes, dackel (dak), pectoral fin buds form initially, but later the fin epithelium fails to expand. Expression of sonic hedgehog mRNA in the posterior mesenchyme of the pectoral fin bud is initiated in dak embryos, but not maintained. Mutations in five other genes affect adult fin but not larval fin development. Two mutants, longfin (lof) and another longfin (alf) have generally longer fins. Stein und bein (sub) has reduced dorsal and pelvic fins, whereas finless (fls) and wanda (wan) mutants affect all adult fins. Finally, mutations in four genes causing defects in embryonic skin formation will be briefly reported.