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Journal Article

Control of leaf morphogenesis by microRNAs

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Palatnik,  JF
Department Molecular Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Schommer,  C
Department Molecular Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Schwab,  R
Department Molecular Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Weigel,  D
Department Molecular Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Citation

Palatnik, J., Allen, E., Wu, X., Schommer, C., Schwab, R., Carrington, J., et al. (2003). Control of leaf morphogenesis by microRNAs. Nature, 425(6955), 257-263. doi:10.1038/nature01958.


Cite as: https://hdl.handle.net/21.11116/0000-000A-8EB6-9
Abstract
Plants with altered microRNA metabolism have pleiotropic developmental defects, but direct evidence for microRNAs regulating specific aspects of plant morphogenesis has been lacking. In a genetic screen, we identified the JAW locus, which produces a microRNA that can guide messenger RNA cleavage of several TCP genes controlling leaf development. MicroRNA-guided cleavage of TCP4 mRNA is necessary to prevent aberrant activity of the TCP4 gene expressed from its native promoter. In addition, overexpression of wild-type and microRNA-resistant TCP variants demonstrates that mRNA cleavage is largely sufficient to restrict TCP function to its normal domain of activity. TCP genes with microRNA target sequences are found in a wide range of species, indicating that microRNA-mediated control of leaf morphogenesis is conserved in plants with very different leaf forms.