A combined X-ray scattering and simulation study of halothane in membranes at 
raised pressures

McCarthy, NLC; Brooks, NJ; Tyler, AII; ElGamacy, M; Welche, PRL; Payne, MC; Chau, P-L

doi:10.1016/j.cplett.2016.12.041

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A combined X-ray scattering and simulation study of halothane in membranes at raised pressures

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ElGamacy, M
Department Protein Evolution, Max Planck Institute for Developmental Biology, Max Planck Society;

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Citation

McCarthy, N., Brooks, N., Tyler, A., ElGamacy, M., Welche, P., Payne, M., et al. (2017). A combined X-ray scattering and simulation study of halothane in membranes at raised pressures. Chemical Physics Letters, 671, 21-27. doi:10.1016/j.cplett.2016.12.041.

Cite as: https://hdl.handle.net/21.11116/0000-000A-925F-7

Abstract

Using a combination of high pressure wide angle X-ray scattering experiments and molecular dynamics simulations, we probe the effect of the archetypal general anaesthetic halothane on the lipid hydrocarbon chain packing and ordering in model bilayers and the variation in these parameters with pressure. Incorporation of halothane into the membrane causes an expansion of the lipid hydrocarbon chain packing at all pressures. The effect of halothane incorporation on the hydrocarbon chain order parameter is significantly reduced at elevated pressure.