English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Homotypic cell competition regulates proliferation and tiling of zebrafish pigment cells during colour pattern formation

MPS-Authors
/persons/resource/persons191368

Walderich,  B
Research Group Colour Pattern Formation, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons272160

Singh,  AP
Research Group Colour Pattern Formation, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons274122

Mahalwar,  P
Research Group Colour Pattern Formation, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons271460

Nüsslein-Volhard,  C
Research Group Colour Pattern Formation, Max Planck Institute for Developmental Biology, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Walderich, B., Singh, A., Mahalwar, P., & Nüsslein-Volhard, C. (2016). Homotypic cell competition regulates proliferation and tiling of zebrafish pigment cells during colour pattern formation. Nature Communications, 7: 11462. doi:10.1038/ncomms11462.


Cite as: https://hdl.handle.net/21.11116/0000-000A-93E2-0
Abstract
The adult striped pattern of zebrafish is composed of melanophores, iridophores and xanthophores arranged in superimposed layers in the skin. Previous studies have revealed that the assembly of pigment cells into stripes involves heterotypic interactions between all three chromatophore types. Here we investigate the role of homotypic interactions between cells of the same chromatophore type. Introduction of labelled progenitors into mutants lacking the corresponding cell type allowed us to define the impact of competitive interactions via long-term in vivo imaging. In the absence of endogenous cells, transplanted iridophores and xanthophores show an increased rate of proliferation and spread as a coherent net into vacant space. By contrast, melanophores have a limited capacity to spread in the skin even in the absence of competing endogenous cells. Our study reveals a key role for homotypic competitive interactions in determining number, direction of migration and individual spacing of cells within chromatophore populations.