Cohort profile: The LIFE-adult-study

Engel, Christoph; Wirkner, Kerstin; Zeynalova, Samira; Baber, Ronny; Binder, Hans; Ceglarek, Uta; Enzenbach, Cornelia; Fuchs, Michael; Hagendorff, Andreas; Henger, Sylvia; Hinz, Andreas; Rauscher, Franziska G; Reusche, Matthias; Riedel-Heller, Steffi G; Röhr, Susanne; Sacher, Julia; Sander, Christian; Schroeter, Matthias L.; Tarnok, Attila; Treudler, Regina; Villringer, Arno; Wachter, Rolf; Witte, A. Veronica; Thiery, Joachim; Scholz, Markus; Loeffler, Markus; LIFE-Adult-Study working group

doi:10.1093/ije/dyac114

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Cohort profile: The LIFE-adult-study

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Sacher, Julia
Clinic for Cognitive Neurology, University of Leipzig, Germany;
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Schroeter, Matthias L.
Clinic for Cognitive Neurology, University of Leipzig, Germany;
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Villringer, Arno
Clinic for Cognitive Neurology, University of Leipzig, Germany;
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Witte, A. Veronica
Clinic for Cognitive Neurology, University of Leipzig, Germany;
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Zitation

Engel, C., Wirkner, K., Zeynalova, S., Baber, R., Binder, H., Ceglarek, U., et al. (2022). Cohort profile: The LIFE-adult-study. International Journal of Epidemiology. doi:10.1093/ije/dyac114.

Zitierlink: https://hdl.handle.net/21.11116/0000-000A-951C-F

Zusammenfassung

The LIFE-Adult-Study is a population-based cohort study investigating the prevalence and incidence of common diseases and subclinical disease phenotypes, the complex interactions between genetic and lifestyle factors regarding the co-occurrence and development of subclinical phenotypes and diseases, and the role of biomarkers to predict disease initiation and progression.

The study comprises an age-stratified and sex-stratified random sample of 10 000 adult individuals (aged 18–79 years) from Leipzig, Germany. The baseline assessment was conducted from August 2011 to November 2014 and the first follow-up was conducted from October 2017 to August 2021. A total of 5512 individuals completed postal follow-up questionnaires and 1799 individuals participated in a physical examination follow-up programme.

The study focuses on cardiovascular and metabolic disorders, cognition and brain function, depression, sleep disorders and electroencephalography-vigilance regulation, eye diseases, voice and allergies. The assessment programme comprises physical and medical examinations, personal interviews, self-administered questionnaires, psychometric tests, and clinical chemistry from blood and urine samples (including biobank asservation).