Genetics of early-life head circumference and genetic correlations with 
neurological, psychiatric and cognitive outcomes

Vogelezang, Suzanne; Bradfield, Jonathan P.; the Early Growth Genetics Consortium,; Grant, Struan F. A.; Felix, Janine F.; Jaddoe, Vincent W. V.

doi:10.1186/s12920-022-01281-1

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes

MPS-Authors

the Early Growth Genetics Consortium,
Language and Genetics Department, MPI for Psycholinguistics, Max Planck Society;
Population genetics of human communication, MPI for Psycholinguistics, Max Planck Society;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

Vogelezang_etal_2022_Genetics of early life circumference....pdf
(Publisher version), 2MB

Supplementary Material (public)

Vogelezang_etal_2022supp1_Genetics of early life circumference....docx
(Supplementary material), 250KB

Vogelezang_etal_2022supp2_Genetics of early life circumference....xlsx
(Supplementary material), 30KB

Vogelezang_etal_2022supp3_Genetics of early life circumference....xlsx
(Supplementary material), 169KB

Vogelezang_etal_2022supp4_Genetics of early life circumference....xlsx
(Supplementary material), 25KB

Citation

Vogelezang, S., Bradfield, J. P., the Early Growth Genetics Consortium, Grant, S. F. A., Felix, J. F., & Jaddoe, V. W. V. (2022). Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes. BMC Medical Genomics, 15: 124. doi:10.1186/s12920-022-01281-1.

Cite as: https://hdl.handle.net/21.11116/0000-000A-95D2-0

Abstract

Background

Head circumference is associated with intelligence and tracks from childhood into adulthood.
Methods

We performed a genome-wide association study meta-analysis and follow-up of head circumference in a total of 29,192 participants between 6 and 30 months of age.
Results

Seven loci reached genome-wide significance in the combined discovery and replication analysis of which three loci near ARFGEF2, MYCL1, and TOP1, were novel. We observed positive genetic correlations for early-life head circumference with adult intracranial volume, years of schooling, childhood and adult intelligence, but not with adult psychiatric, neurological, or personality-related phenotypes.
Conclusions

The results of this study indicate that the biological processes underlying early-life head circumference overlap largely with those of adult head circumference. The associations of early-life head circumference with cognitive outcomes across the life course are partly explained by genetics.