Synergistic in vitro interaction of isavuconazole and isoquercitrin against 
Candida glabrata

Schwarz, Petra V.; Nikolskiy, Ilya; Dannaoui, Eric; Sommer, Frank; Bange, Gert; Schwarz, Patrick

doi:10.3390/jof8050525

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Synergistic in vitro interaction of isavuconazole and isoquercitrin against Candida glabrata

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Bange, Gert
Max Planck Fellow Molecular Physiology of Microbes, Max Planck Institute for Terrestrial Microbiology, Max Planck Society;
Philipps-Universität Marburg, Center for Synthetic Microbiology;
Philipps-Universität Marburg, Department Chemistry;

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https://doi.org/10.3390/jof8050525
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Citation

Schwarz, P. V., Nikolskiy, I., Dannaoui, E., Sommer, F., Bange, G., & Schwarz, P. (2022). Synergistic in vitro interaction of isavuconazole and isoquercitrin against Candida glabrata. Journal of Fungi, 8(5): 525. doi:10.3390/jof8050525.

Cite as: https://hdl.handle.net/21.11116/0000-000A-9CD6-5

Abstract

In vitro interactions of broad-spectrum azole isavuconazole with flavonoid isoquercitrin were evaluated by a broth microdilution checkerboard technique based on the European Committee on Antimicrobial Susceptibility Testing (EUCAST) reference methodology for antifungal susceptibility testing against 60 Candida strains belonging to the species Candida albicans (n = 10), Candida glabrata (n = 30), Candida kefyr (n = 6), Candida krusei (n = 5), Candida parapsilosis (n = 4), and Candida tropicalis (n = 5). The results were analyzed with the fractional inhibitory concentration index and by response surface analysis based on the Bliss model. Synergy was found for all C. glabrata strains, when the results were interpreted by the fractional inhibitory concentration index, and for 60% of the strains when response surface analysis was used. Interaction for all other species was indifferent for all strains tested, whatever interpretation model used. Importantly, antagonistic interaction was never observed.