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Journal Article

Ubiquitin facilitates a quality-control pathway that removes damaged chloroplasts

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Salomé,  PA
Department Molecular Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Weigel,  D
Department Molecular Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Citation

Woodson, J., Joens, M., Sinson, A., Gilkerson, J., Salomé, P., Weigel, D., et al. (2015). Ubiquitin facilitates a quality-control pathway that removes damaged chloroplasts. Science, 350(6295), 450-454. doi:10.1126/science.aac7444.


Cite as: https://hdl.handle.net/21.11116/0000-000A-9DEF-9
Abstract
Energy production by chloroplasts and mitochondria causes constant oxidative damage. A functioning photosynthetic cell requires quality-control mechanisms to turn over and degrade chloroplasts damaged by reactive oxygen species (ROS). Here, we generated a conditionally lethal Arabidopsis mutant that accumulated excess protoporphyrin IX in the chloroplast and produced singlet oxygen. Damaged chloroplasts were subsequently ubiquitinated and selectively degraded. A genetic screen identified the plant U-box 4 (PUB4) E3 ubiquitin ligase as being necessary for this process. pub4-6 mutants had defects in stress adaptation and longevity. Thus, we have identified a signal that leads to the targeted removal of ROS-overproducing chloroplasts.