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Journal Article

Antimicrobial diterpene alkaloids from an Agelas Citrina sponge collected in the Yucatán Peninsula

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Fuentes-Monteverde,  J. C.
Department of NMR Based Structural Biology, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

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Griesinger,  C.       
Department of NMR Based Structural Biology, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

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Citation

Pech-Puch, D., Forero, A. M., Fuentes-Monteverde, J. C., Lasarte-Monterrubio, C., Martinez-Guitian, M., González-Salas, C., et al. (2022). Antimicrobial diterpene alkaloids from an Agelas Citrina sponge collected in the Yucatán Peninsula. Marine Drugs, 20(5): 298. doi:10.3390/md20050298.


Cite as: https://hdl.handle.net/21.11116/0000-000A-CB72-1
Abstract
Three new diterpene alkaloids, (+)-8-epiagelasine T (1), (+)-10-epiagelasine B (2), and (+)-12-hydroxyagelasidine C (3), along with three known compounds, (+)-ent-agelasine F (4), (+)-agelasine B (5), and (+)-agelasidine C (6), were isolated from the sponge Agelas citrina, collected on the coasts of the Yucatan Peninsula (Mexico). Their chemical structures were elucidated by 1D and 2D NMR spectroscopy, HRESIMS techniques, and a comparison with literature data. Although the synthesis of (+)-ent-agelasine F (4) has been previously reported, this is the first time that it was isolated as a natural product. The evaluation of the antimicrobial activity against the Gram-positive pathogens Staphylococcus aureus, Streptococcus pneumoniae, Enterococcus faecalis showed that all of them were active, with (+)-10-epiagelasine B (2) being the most active compound with an MIC in the range of 1-8 mu g/mL. On the other hand, the Gram-negative pathogenes Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae were also evaluated, and only (+)-agelasine B (5) showed a moderate antibacterial activity with a MIC value of 16 mu g/mL.