Adenylate cyclase 5 is required for melanophore and male pattern development in 
the guppy (Poecilia reticulata)

Kottler, VA; Künstner, A; Koch, I; Flötenmeyer, M; Langenecker, T; Hoffmann, M; Sharma, E; Weigel, D; Dreyer, C

doi:10.1111/pcmr.12386

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Adenylate cyclase 5 is required for melanophore and male pattern development in the guppy (Poecilia reticulata)

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Kottler, VA
Department Molecular Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons136841

Künstner, A
Department Molecular Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons273470

Koch, I
Electron Microscopy, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons272636

Flötenmeyer, M
Electron Microscopy, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons271488

Langenecker, T
Department Molecular Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons272554

Hoffmann, M
Department Molecular Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons274275

Sharma, E
Department Molecular Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons85266

Weigel, D
Department Molecular Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons272562

Dreyer, C
Department Molecular Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Citation

Kottler, V., Künstner, A., Koch, I., Flötenmeyer, M., Langenecker, T., Hoffmann, M., et al. (2015). Adenylate cyclase 5 is required for melanophore and male pattern development in the guppy (Poecilia reticulata). Pigment Cell & Melanoma Research, 28(5), 545-558. doi:10.1111/pcmr.12386.

Cite as: https://hdl.handle.net/21.11116/0000-000A-A357-C

Abstract

Guppies (Poecilia reticulata) are colorful fish that have attracted the attention of pigmentation researchers for almost a century. Here, we report that the blond phenotype of the guppy is caused by a spontaneous mutation in the guppy ortholog of adenylate cyclase 5 (adcy5). Using double digest restriction site-associated DNA sequencing (ddRADseq) and quantitative trait locus (QTL) mapping, we linked the blond phenotype to a candidate region of 118 kb, in which we subsequently identified a 2-bp deletion in adcy5 that alters splicing and leads to a premature stop codon. We show that adcy5, which affects lifespan and melanoma growth in mouse, is required for melanophore development and formation of male orange pigmentation traits in the guppy. We find that some components of the male orange pattern are particularly sensitive to loss of Adcy5 function. Our work thus reveals a function for Adcy5 in patterning of fish color ornaments.