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Journal Article

Neurons as a model system for cryo-electron tomography


Lucic,  V.
Baumeister, Wolfgang / Molecular Structural Biology, Max Planck Institute of Biochemistry, Max Planck Society;

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Zuber, B., & Lucic, V. (2022). Neurons as a model system for cryo-electron tomography. Journal of Structural Biology: X, 6: 100067. doi:10.1016/j.yjsbx.2022.100067.

Cite as: https://hdl.handle.net/21.11116/0000-000A-A3B8-E
Cryo-electron tomography (Cryo-ET) provides unique opportunities to image cellular components at high resolution in their native state and environment. While many different cell types were investigated by cryo-ET, here we review application to neurons. We show that neurons are a versatile system that can be used to investigate general cellular components such as the cytoskeleton and membrane-bound organelles, in addition to neuron specific processes such as synaptic transmission. Furthermore, the synapse provides a rich environment for the development of cryo-ET image processing tools suitable to elucidate the functional and spatial organization of compositionally and morphologically heterogeneous macromolecular complexes involved in biochemical signaling cascades, within their native, crowded cellular environments.