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Strongyloides stercoralis genotypes in humans in Cambodia

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Guo,  L
Department Integrative Evolutionary Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Streit,  A
Department Integrative Evolutionary Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Citation

Schär, F., Guo, L., Streit, A., Khieu, V., Muth, S., Marti, H., et al. (2014). Strongyloides stercoralis genotypes in humans in Cambodia. Parasitology International, 63(3), 533-536. doi:10.1016/j.parint.2014.01.010.


Cite as: http://hdl.handle.net/21.11116/0000-000A-A859-5
Abstract
Little is known about the genetic variability of the soil-transmitted nematode, Strongyloides stercoralis, in humans. We sequenced portions of the small subunit rDNA (SSU), including the hyper variable regions (HVR) I and IV from S. stercoralis larvae derived from individuals living in a rural setting in Cambodia. We identified three polymorphic positions, including a previously reported one within the HVR I. HVR IV was invariable. Six different SSU alleles existed in our sample. Although different genotypes of S. stercoralis were found in the same individuals, no heterozygous larvae were found. This indicates that there is no or very little interbreeding between the different genotypes. Further studies are needed to examine if this is because sexual reproduction, which is facultative, is rare in our study area's S. stercoralis population or because what is considered to be S. stercoralis today is actually a complex of closely related species or subspecies.