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Journal Article

Complex small-molecule architectures regulate phenotypic plasticity in a nematode

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Ogawa,  A
Department Integrative Evolutionary Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Ragsdale,  EJ
Department Integrative Evolutionary Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Sommer,  RJ
Department Integrative Evolutionary Biology, Max Planck Institute for Developmental Biology, Max Planck Society;

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Citation

Bose, N., Ogawa, A., von Reuss, S., Yim, J., Ragsdale, E., Sommer, R., et al. (2012). Complex small-molecule architectures regulate phenotypic plasticity in a nematode. Angewandte Chemie, International Edition in English, 51(50), 12438-12443. doi:10.1002/anie.201206797.


Cite as: https://hdl.handle.net/21.11116/0000-000A-A8F8-1
Abstract
Chemistry the worm's way: The nematode Pristionchus pacificus constructs elaborate small molecules from modified building blocks of primary metabolism, including an unusual xylopyranose-based nucleoside (see scheme). These compounds act as signaling molecules to control adult phenotypic plasticity and dauer development and provide examples of modular generation of structural diversity in metazoans.