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Journal Article

Neuronal connectome of a sensory-motor circuit for visual navigation

MPS-Authors
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Randel,  N
Research Group Neurobiology of Marine Zooplankton, Max Planck Institute for Developmental Biology, Max Planck Society;

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Asadulina,  A
Research Group Neurobiology of Marine Zooplankton, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons273014

Bezares-Calderón,  LA
Research Group Neurobiology of Marine Zooplankton, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons84766

Verasztó,  C
Research Group Neurobiology of Marine Zooplankton, Max Planck Institute for Developmental Biology, Max Planck Society;

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Williams,  EA
Research Group Neurobiology of Marine Zooplankton, Max Planck Institute for Developmental Biology, Max Planck Society;

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Conzelmann,  M
Research Group Neurobiology of Marine Zooplankton, Max Planck Institute for Developmental Biology, Max Planck Society;

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Shahidi,  R
Research Group Neurobiology of Marine Zooplankton, Max Planck Institute for Developmental Biology, Max Planck Society;

/persons/resource/persons85269

Jékely,  G
Research Group Neurobiology of Marine Zooplankton, Max Planck Institute for Developmental Biology, Max Planck Society;

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Citation

Randel, N., Asadulina, A., Bezares-Calderón, L., Verasztó, C., Williams, E., Conzelmann, M., et al. (2014). Neuronal connectome of a sensory-motor circuit for visual navigation. eLife, 3: e02730. doi:10.7554/eLife.02730.


Cite as: https://hdl.handle.net/21.11116/0000-000A-A952-B
Abstract
Animals use spatial differences in environmental light levels for visual navigation; however, how light inputs are translated into coordinated motor outputs remains poorly understood. Here we reconstruct the neuronal connectome of a four-eye visual circuit in the larva of the annelid Platynereis using serial-section transmission electron microscopy. In this 71-neuron circuit, photoreceptors connect via three layers of interneurons to motorneurons, which innervate trunk muscles. By combining eye ablations with behavioral experiments, we show that the circuit compares light on either side of the body and stimulates body bending upon left-right light imbalance during visual phototaxis. We also identified an interneuron motif that enhances sensitivity to different light intensity contrasts. The Platynereis eye circuit has the hallmarks of a visual system, including spatial light detection and contrast modulation, illustrating how image-forming eyes may have evolved via intermediate stages contrasting only a light and a dark field during a simple visual task.