Isoflurane does not aggregate inside POPC bilayers at high pressure: 
Implications for pressure reversal of general anaesthesia

Wietaska, JR; Welche, PRL; ElGamacy, M; Csanyi, G; Payne, MC; Chau, P-L

doi:10.1016/j.cplett.2015.07.065

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Isoflurane does not aggregate inside POPC bilayers at high pressure: Implications for pressure reversal of general anaesthesia

MPS-Authors

/persons/resource/persons271238

ElGamacy, M
Department Protein Evolution, Max Planck Institute for Developmental Biology, Max Planck Society;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Wietaska, J., Welche, P., ElGamacy, M., Csanyi, G., Payne, M., & Chau, P.-L. (2015). Isoflurane does not aggregate inside POPC bilayers at high pressure: Implications for pressure reversal of general anaesthesia. Chemical Physics Letters, 638, 116-121. doi:10.1016/j.cplett.2015.07.065.

Cite as: https://hdl.handle.net/21.11116/0000-000A-AA50-C

Abstract

We placed isoflurane, a general anaesthetic, inside palmitoyloleoylphosphatidylcholine (POPC) bilayers at clinical concentration, and performed molecular dynamics simulations at atmospheric and raised pressures, using two different thermodynamic ensembles. We also performed a simulation of this system with isoflurane at ten times the clinical concentration. We found that isoflurane did not aggregate inside POPC membranes at 20 MPa, nor at 40 MPa. The implications of these findings for pressure reversal is discussed, in light of the high-pressure neurological syndrome.