English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse
  1. View item / 
  2. Item Summary

Item

ITEM ACTIONSEXPORT
Add to Basket
  Local TagsRelease HistoryDetailsSummary

Released
Thesis

Synthesis of oligosaccharide antigens as glycoconjugate vaccine candidates against bacterial pathogens

MPS-Authors
/persons/resource/persons260135

Zhang,  Shuo
Peter H. Seeberger - Vaccine Development, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)

Thesis.pdf
(Any fulltext), 8MB

Supplementary Material (public)
There is no public supplementary material available
Citation

Zhang, S. (2022). Synthesis of oligosaccharide antigens as glycoconjugate vaccine candidates against bacterial pathogens. PhD Thesis, Freie Universität, Berlin.


Cite as: https://hdl.handle.net/21.11116/0000-000A-AF85-B
Abstract
Capsular polysaccharides (CPSs) from the bacterial cell surface are important virulence factors and play an essential role for bacterial survival. CPSs are also important antigens capable of inducing a specific immune response rending these structurally unique glycans attractive targets for antibacterial vaccines development. The first part of the dissertation describes the construction of a collection of 15 novel synthetic oligosaccharides resembling the capsular polysaccharides of Streptococcus suis serotype 9. Differently protected monosaccharide building blocks were synthesized and employed into glycosylations to assemble the oligosaccharides. The second part of the dissertation focused on a multi-drug resistant bacterium Acinetobacter baumannii. The synthesis of repeating unit of CPS from A. baumannii AB5075 as well as two analogues is described. The synthetic oligosaccharides bearing an amine linker are ready for glycan microarray study, identification of the minimal epitope and conjugation.