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Journal Article

Recent advances in the understanding of autophagosome biogenesis


Graef,  M.
Graef – Autophagy and Cellular Ageing, Max Planck Research Groups, Max Planck Institute for Biology of Ageing, Max Planck Society;

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Graef, M. (2020). Recent advances in the understanding of autophagosome biogenesis. F1000Res, 9. doi:10.12688/f1000research.22111.1.

Cite as: https://hdl.handle.net/21.11116/0000-000B-2D95-B
Autophagy is a conserved catabolic process critical for cell homeostasis with broad implications for aging and age-associated diseases. A defining feature of autophagy is the de novo formation of a specialized transient organelle, the double-membrane autophagosome. Autophagosomes originate from small vesicular precursors after rapid membrane expansion resulting in the engulfment of a broad spectrum of cytoplasmic cargoes within a few minutes for vacuolar or lysosomal degradation. Recent advances have provided exciting new insights into the molecular mechanisms underlying the assembly of autophagic membranes during autophagosome biogenesis. Specifically, the phospholipid biosynthesis activity of the endoplasmic reticulum and a dedicated membrane-tethering complex between nascent autophagosomes and the endoplasmic reticulum have emerged as key factors in autophagosome formation.