The RATIOnal Role of Polyamines in Epidermal Differentiation

Allmeroth, K.; Denzel, M.

doi:10.1016/j.jid.2021.02.011

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The RATIOnal Role of Polyamines in Epidermal Differentiation

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Allmeroth, K.
Denzel – Metabolic and Genetic Regulation of Ageing, Research Groups, Max Planck Institute for Biology of Ageing, Max Planck Society;

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Denzel, M.
Denzel – Metabolic and Genetic Regulation of Ageing, Research Groups, Max Planck Institute for Biology of Ageing, Max Planck Society;

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https://www.ncbi.nlm.nih.gov/pubmed/34420674
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Citation

Allmeroth, K., & Denzel, M. (2021). The RATIOnal Role of Polyamines in Epidermal Differentiation. J Invest Dermatol, 141(9), 2105-2107. doi:10.1016/j.jid.2021.02.011.

Cite as: https://hdl.handle.net/21.11116/0000-000A-F8D2-1

Abstract

Polyamines have been implicated in skin tumorigenesis; however, their role in epidermal homeostasis remains obscure. In a new article in the Journal of Investigative Dermatology, Rahim et al. (2021) report that keratinocyte differentiation requires a shift in polyamine ratios that is mediated by AMD1. Results suggest that targeting polyamine availability might be useful in the treatment of hyperproliferative skin disorders.