Nuclear pore complex assembly through the cell cycle: regulation and membrane 
organization

Antonin, W; Ellenberg, J; Dultz, E

doi:10.1016/j.febslet.2008.02.067

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Nuclear pore complex assembly through the cell cycle: regulation and membrane organization

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Antonin, W
Antonin Group, Friedrich Miescher Laboratory, Max Planck Society;

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Antonin, W., Ellenberg, J., & Dultz, E. (2008). Nuclear pore complex assembly through the cell cycle: regulation and membrane organization. FEBS Letters, 582(14), 2004-2016. doi:10.1016/j.febslet.2008.02.067.

Cite as: https://hdl.handle.net/21.11116/0000-000A-B03A-E

Abstract

In eukaryotes, all macromolecules traffic between the nucleus and the cytoplasm through nuclear pore complexes (NPCs), which are among the largest supramolecular assemblies in cells. Although their composition in yeast and metazoa is well characterized, understanding how NPCs are assembled and form the pore through the double membrane of the nuclear envelope and how both processes are controlled still remains a challenge. Here, we summarize what is known about the biogenesis of NPCs throughout the cell cycle with special focus on the membrane reorganization and the regulation that go along with NPC assembly.