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Journal Article

Tip20p prohibits back-fusion of COPII vesicles with the endoplasmic reticulum

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Kamena,  F
Spang Group, Friedrich Miescher Laboratory, Max Planck Society;

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Spang,  A
Spang Group, Friedrich Miescher Laboratory, Max Planck Society;

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Citation

Kamena, F., & Spang, A. (2004). Tip20p prohibits back-fusion of COPII vesicles with the endoplasmic reticulum. Science, 304(5668), 286-289. doi:10.1126/science.1095049.


Cite as: http://hdl.handle.net/21.11116/0000-000A-B0AA-F
Abstract
Directionality in intracellular trafficking is essential to ensure the correct localization of proteins along the secretory pathway. Here, we found evidence for an active mechanism that prohibited back-fusion of de novo-generated vesicles with their donor compartment. Tip20p is a peripheral membrane protein implicated in consumption of COPI vesicles at the endoplasmic reticulum. However, a specific mutant of TIP20 did not interfere with COPII vesicle generation but allowed these vesicles to fuse back to the endoplasmic reticulum, a process that does not occur normally in the cell.