Single-channel parameters of gramicidin a,b, and c

Bamberg, E.; Noda, K.; Läuger, P.

doi:10.1016/0005-2736(76)90348-5

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Single-channel parameters of gramicidin a,b, and c

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Bamberg, E., Noda, K., & Läuger, P. (1976). Single-channel parameters of gramicidin a,b, and c. Biochimica et Biophysica Acta: BBA, 419(2), 223-228. doi:10.1016/0005-2736(76)90348-5.

Cite as: https://hdl.handle.net/21.11116/0000-000A-C29A-D

Abstract

The single-channel conductance Λ and the mean channel lifetime τ∗ of natural and synthetic gramicidins A, B, and C has been studied. Significant differences in Λ were found between gramicidin A and B; both gramicidins differ only in one amino acid (tryptophan replaced by phenylalinine). The distribution of Λ is narrow in glycerylmonooleate membranes but considerably broader in dioleoyl phosphatidylcholine and dioleoyl phosphatidylethanolamine membranes. The ratio of the single-channel conductances in glycerylmonooleate and dioleoyl phosphatidylcholine membranes is only about two and is considerable smaller than the conductance ratio of nonactin-mediated cation transport. This finding suggests that dipolar potentials at the membrane/solution interface have little influence on the conductance of the gramicidin channel.