Effects of surface charge on the conductance of the gramicidin channel

Apell, H. -J; Bamberg, E.; Läuger, P

doi:10.1016/0005-2736(79)90181-0

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Effects of surface charge on the conductance of the gramicidin channel

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Apell, H.-.-J., Bamberg, E., & Läuger, P. (1979). Effects of surface charge on the conductance of the gramicidin channel. Biochimica et Biophysica Acta: BBA, 552(3), 369-378. doi:10.1016/0005-2736(79)90181-0.

Cite as: https://hdl.handle.net/21.11116/0000-000A-C764-5

Abstract

The electric conductance of the cation-permeable gramicidin channel in negatively charged phosphatidylserine membranes has been studied. At low electrolyte concentrations the single-channel conductance is much larger in the negatively charged membrane than in a neutral membrane. This enhancement of conductance is in agreement with theoretical expectations, although a complete description of the salt concentration dependence of conductance was not possible. The results of these experiments may be compared with previous studies of a negatively charged gramicidin analog (O-pyromellityl gramicidin). It is found that the electrostatic effect on the conductance is much larger for a neutral channel embedded in a negatively charged lipid than for the negatively charged O-pyromellityl analog (with three charges at the channel mouth) embedded in a neutral lipid.