Help Privacy Policy Disclaimer
  Advanced SearchBrowse




Journal Article

Effects of surface charge on the conductance of the gramicidin channel

There are no MPG-Authors in the publication available
External Resource

(Any fulltext)

Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available

Apell, H.-.-J., Bamberg, E., & Läuger, P. (1979). Effects of surface charge on the conductance of the gramicidin channel. Biochimica et Biophysica Acta: BBA, 552(3), 369-378. doi:10.1016/0005-2736(79)90181-0.

Cite as: https://hdl.handle.net/21.11116/0000-000A-C764-5
The electric conductance of the cation-permeable gramicidin channel in negatively charged phosphatidylserine membranes has been studied. At low electrolyte concentrations the single-channel conductance is much larger in the negatively charged membrane than in a neutral membrane. This enhancement of conductance is in agreement with theoretical expectations, although a complete description of the salt concentration dependence of conductance was not possible. The results of these experiments may be compared with previous studies of a negatively charged gramicidin analog (O-pyromellityl gramicidin). It is found that the electrostatic effect on the conductance is much larger for a neutral channel embedded in a negatively charged lipid than for the negatively charged O-pyromellityl analog (with three charges at the channel mouth) embedded in a neutral lipid.