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Journal Article

Bimodal Fluorescence/Magnetic Resonance Molecular Probes with Extended Spin Lifetimes

MPS-Authors
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Yang,  S.
Research Group of NMR Signal Enhancement, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

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Saul,  P.
Research Group of NMR Signal Enhancement, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

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Mamone,  S.
Research Group of NMR Signal Enhancement, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

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Kaltschnee,  L.
Research Group of NMR Signal Enhancement, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

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Glöggler,  Stefan
Research Group of NMR Signal Enhancement, Max Planck Institute for Multidisciplinary Sciences, Max Planck Society;

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Fulltext (public)

3398236.pdf
(Publisher version), 825KB

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Citation

Yang, S., Saul, P., Mamone, S., Kaltschnee, L., & Glöggler, S. (2022). Bimodal Fluorescence/Magnetic Resonance Molecular Probes with Extended Spin Lifetimes. Chemistry – A European Journal, 28(8): e202104158. doi:10.1002/chem.202104158.


Cite as: http://hdl.handle.net/21.11116/0000-000A-D29C-9
Abstract
Bimodal molecular probes combining nuclear magnetic resonance (NMR) and fluorescence have been widely studied in basic science, as well as clinical research. The investigation of spin phenomena holds promise to broaden the scope of available probes allowing deeper insights into physiological processes. Herein, a class of molecules with a bimodal character with respect to fluorescence and nuclear spin singlet states is introduced. Singlet states are NMR silent but can be probed indirectly. Symmetric, perdeuterated molecules, in which the singlet states can be populated by vanishingly small electron-mediated couplings (below 1 Hz) are reported. The lifetimes of these states are an order of magnitude longer than the longitudinal relaxation times and up to four minutes at 7 T. Moreover, these molecules show either aggregation induced emission (AIE) or aggregation caused quenching (ACQ) with respect to their fluorescence. In the latter case, the existence of excited dimers, which are proposed to use in a switchable manner in combination with the quenching of nuclear spin singlet states, is observed