English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Meeting Abstract

7T multi-pool CEST MRI in multiple sclerosis patients

MPS-Authors
/persons/resource/persons214560

Zaiss,  M
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Fabian, M., Hock, S., Mennecke, A., Schmidt, M., Dörfler, A., & Zaiss, M. (2022). 7T multi-pool CEST MRI in multiple sclerosis patients. In 9th International Workshop on Chemical Exchange Saturation Transfer Imaging (CEST 2022) (pp. 31).


Cite as: https://hdl.handle.net/21.11116/0000-000A-D601-3
Abstract
7T multi-pool CEST MRI in multiple sclerosis patients
Moritz Simon Fabian1, Stefan Hock1, Angelika Barbara Mennecke1, Manuel Schmidt1, Arnd Dörfler1, and Moritz Zaiß1,2
1Institute of Neuroradiology, University Hospital Erlangen, Erlangen, Germany, 2High-field Magnetic Resonance Center,
Max Planck Institute for Biological Cybernetics, Tübingen, Germany
! Either Oral or Poster Presentation | Contact Email: Moritz.fabian@uk-erlangen.de
KEYWORD: ! Neurology
Introduction For Multiple Sclerosis
(MS), it is crucial to detect lesions and
classify the MS-type as early as
possible, in order to optimize
treatment.[1,2] Interestingly, CEST MRI
at 7T has shown to yield correlations
with Gadolinium (Gd) contrast
enhancement in tumours.[3] In this work,
we are testing the same CEST approach
in patients suffering from multiple
sclerosis.
Methods Data were acquired from 3
patients (Relapsing Remitting MS
RRMS: 2, Radiologic Isolated Syndrom
RIS: 1), after written informed consent
and under approval of the local ethics
committee, at a MAGNETOM Terra 7
Tesla scanner (Siemens Healthcare
GmbH, Erlangen, Germany) with an
32ch Rx and 8ch Tx head coil.
Homogeneous Gaussian pre-saturation
was realized using the MIMOSA scheme
(120 pulses, tp=15 ms, duty cycle
!"#$%&'$()*+,*,-.*/0*123214*.5*%&6789*
+:;*0&%%89&[4] Image readout was a centric
3D snapshot GRE [5]. GRAPPA 2 was applied in the first phase encoding direction [6]. 56 frequency offsets were
distributed non-equidistantly between -100 and 100 ppm, finer between -5 and 5 ppm. The evaluation of CEST data was
done according to [7,8].
Results CEST parameter amplitudes and clinical imgaging of a RRMS patient are shown in Figure 1. Regions of interest
<=>?@4) were drawn by a trained neuroradiologist to capture a variety of inactive (old), active lesions and appropriate
reference tissue. Our main hypothesis, that Gd enhancement of active MS lesions can also be seen with 7T amide CEST,
could not be clearly verified. Examining the values of the lesion =>?@4*+,*A.B2:,CD+:*5D,*E+B+F2,2B4*G amplitude, peak width
and spectral position G did not yield additional insight. (data not shown).
Discussion With the CEST experiment employed here, MS-Lesions (>3mm diameter) were detectable in CEST
parameter maps. The correlation of amide CEST and Gd enhancement (s.a. [3]) is only given in specific lesions. Direct
correlations of CEST maps and clinical imaging are not confirmable. Together with high information content of CEST in
general, a higher amide CEST value in active lesions G caused by a larger protein content G might originate from an acute
immune reaction in that area. Likewise, a decreased amide/NOE/MT value in inactive regions G paired with a
hypointensity in contrast enhanced T1 weighted imaging G refers to a direct damage of tissue, specifically depletion of
myelin. This aligns well with the results of [9], where MS-Lesions were identified using NOE weighted imaging. In the
findings of [10], separation of lesion type into active and non-active (old) was shown to be possible by applying a higher
B1 level .5*+EEB.HDF+,21I*7&%*8T. This B1 level is more sensitive to the exchange of Glutamate, which is said to be altered
in Multiple Sclerosis lesions.
Conclusion We tested a 7T multi-pool CEST protocol in MS patients, which previously showed Gd-enhancement-like
structures in brain tumors. While some active lesions showed hyperintensities, other active lesions in the three measured
patients did not show a correlation with Gadolinium contrast enhancement.